top of page

Psychedelic Diaries, Vol X: Mastering the macrodose

“The more one meditates upon good thoughts, the better will be ones world and the world at large”


Psychedelic Diaries refresher

This ten-part series chronicles monthly, full-dose, psychedelic therapy over five years. It will cover the insights, challenges, and overall impact.


Mastering the macrodose

This all started because of a crush on a girl.

In the process, I had a number of realizations, discovered the Mozart Zone, and met God.

Psychedelics are our best tool for mental health, creativity, and finding purpose.

And yet, the adventure into your mind can be intimidating.

The first nine articles in these Psychedelic Diaries detailed many nuances of macrodosing... this edition will address my approach to dosage and timing.


There are 3 stages of mastering the psilocybin macrodose:

  1. Getting acquainted

  2. Deep cleanings

  3. Mind maintenance

I’ll share my Sasha-Shulgin-inspired approach to each stage, followed by brief thoughts on microdosing and mushroom cultivation.

Stage 1: Getting acquainted


Get comfortable with the substance and ramp up to full dosage


Proper preparation followed by 3 trips of increasing dosage:

  1. A 0.42g microdose with a walk in the park

  2. 2 weeks later, a half dose (1.75g – 2g) alone or with a copilot, indoors

  3. 1 month later a full dose 3.5g alone or with a copilot, indoors


  • Illuminations that change the trajectory of life in beautiful ways

  • Mind and body are now familiar with the medicine

Stage 2: Deep cleanings


Neural pathways have “gummed up” over the years. A few deep sessions will reset brain connectivity.


Alternating full and half doses, 1x a month, for 4 months

  1. Month 1 — 3.5g alone or with a copilot, indoors

  2. Month 2 — 1.75g alone or with a copilot, in nature

  3. Month 3 — 3.5g alone, indoors

  4. Month 4 — 1.75g alone, in nature


  • The mind will be reset with tremendous connectivity and a quieter default mode network.

  • The effects of the Mozart Zone will be pronounced.

Stage 3: Mind maintenance


Establish a cadence that gives the mind consistent access to full capacity.


A full or half dose on the last Saturday of each month.

Schedule 1 full dose for every 2 half doses. In other words, month 1 is a 3g–4g dose, then month 2 and 3 are half that amount. For example:

  1. January 3.5g

  2. Feb 1.75

  3. Mar 2.5g

Reset the full-half-half cadence each quarter with one caveat: the mind and body may need 6-8 weeks after especially profound trips.

Alternate between these four settings:

  1. Indoors, alone

  2. In nature, with a copilot

  3. Indoors, with a copilot

  4. In nature, alone


  • The mind’s EQ and IQ are asymptote-close to full capacity

  • Drastically improved mental health

  • Profound impact on problem solving and creativity

  • Raised consciousness with a deep sense of purpose

Too much?

It's fair to ask whether this is too much psychedelic therapy.

The clear answer was no for me, and research may support the 1 month cadence.

I experimented with 2, 3, and 4-month breaks... and experienced diminished results.

However, some trips are so powerful that a longer break is ideal, and needs may change over time.

After five years, I've noticed a shift. Perhaps a reduced frequency will feel appropriate.

Microdosing and growing

I utilize 2-5 smaller microdose sessions during the month:

  • 0.07g–0.15g for complex problem solving and creativity at work

  • 0.42g for weekend microdoses

I used Double Blind to learn how to grow and Sporeworks for finding research spores.


In an ineffable space like this, it’s tough to handicap how much psychedelics have already done for us.

It’s just as tough to put an upper bound on the future possibilities.

This psychedelic renaissance is a beautiful thing.

If you're ready, there’s an adventure waiting.


bottom of page